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59 results

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Page 1
CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma.
Yao J, Wang J, Xu Y, Guo Q, Sun Y, Liu J, Li S, Guo Y, Wei L. Yao J, et al. Autophagy. 2022 Aug;18(8):1879-1897. doi: 10.1080/15548627.2021.2007027. Epub 2021 Dec 10. Autophagy. 2022. PMID: 34890308 Free PMC article.
We demonstrated that CDK9 inhibitors promoted dephosphorylation of SIRT1 and promoted FOXO3 protein degradation, which was regulated by its acetylation, leading to the transcriptional repression of FOXO3-driven BNIP3 and impairing the BNIP3-mediated st …
We demonstrated that CDK9 inhibitors promoted dephosphorylation of SIRT1 and promoted FOXO3 protein degradation, which was regulated …
The role of STAT3 in autophagy.
You L, Wang Z, Li H, Shou J, Jing Z, Xie J, Sui X, Pan H, Han W. You L, et al. Autophagy. 2015;11(5):729-39. doi: 10.1080/15548627.2015.1017192. Autophagy. 2015. PMID: 25951043 Free PMC article. Review.
For example, nuclear STAT3 fine-tunes autophagy via the transcriptional regulation of several autophagy-related genes such as BCL2 family members, BECN1, PIK3C3, CTSB, CTSL, PIK3R1, HIF1A, BNIP3, and microRNAs with targets of autophagy modulators. Cytoplasmic STAT3 constit …
For example, nuclear STAT3 fine-tunes autophagy via the transcriptional regulation of several autophagy-related genes such as BCL2 family me …
The multifaceted regulation of mitophagy by endogenous metabolites.
Zhang T, Liu Q, Gao W, Sehgal SA, Wu H. Zhang T, et al. Autophagy. 2022 Jun;18(6):1216-1239. doi: 10.1080/15548627.2021.1975914. Epub 2021 Sep 29. Autophagy. 2022. PMID: 34583624 Free PMC article.
We also highlight the key regulations of mammalian mitophagy by endogenous metabolites, shed new light on the bidirectional interplay between mitophagy and cellular metabolisms, with attempting to provide a perspective insight into the nutritional intervention of metabolic disord …
We also highlight the key regulations of mammalian mitophagy by endogenous metabolites, shed new light on the bidirectional interplay betwee …
ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms.
Li L, Tan J, Miao Y, Lei P, Zhang Q. Li L, et al. Cell Mol Neurobiol. 2015 Jul;35(5):615-21. doi: 10.1007/s10571-015-0166-x. Epub 2015 Feb 27. Cell Mol Neurobiol. 2015. PMID: 25722131 Review.
The internal regulatory mechanisms of autophagy by ROS can be summarized as transcriptional and post-transcriptional regulation, which includes various molecular signal pathways such as ROS-FOXO3-LC3/BNIP3-autophagy, ROS-NRF2-P62-autophagy, ROS-HIF1-BNIP3/NIX …
The internal regulatory mechanisms of autophagy by ROS can be summarized as transcriptional and post-transcriptional regulation, which inclu …
FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress.
Chaanine AH, Kohlbrenner E, Gamb SI, Guenzel AJ, Klaus K, Fayyaz AU, Nair KS, Hajjar RJ, Redfield MM. Chaanine AH, et al. Am J Physiol Heart Circ Physiol. 2016 Dec 1;311(6):H1540-H1559. doi: 10.1152/ajpheart.00549.2016. Epub 2016 Sep 30. Am J Physiol Heart Circ Physiol. 2016. PMID: 27694219 Free PMC article.
Based on previous work, we hypothesized that FOXO3a, through BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 (BNIP3), modulates mitochondrial morphology and function in heart failure (HF). ...Whereas dn-FX3a attenuated the increase in BNIP3 expression and i …
Based on previous work, we hypothesized that FOXO3a, through BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 (BNIP3), modula …
Soluble RAGE attenuates myocardial I/R injuries via FoxO3-Bnip3 pathway.
Zhang J, Han X, Chang J, Liu J, Liu Y, Wang H, Du F, Zeng X, Guo C. Zhang J, et al. Cell Mol Life Sci. 2022 May 2;79(5):269. doi: 10.1007/s00018-022-04307-0. Cell Mol Life Sci. 2022. PMID: 35501612
Therefore, it is supposed that FoxO3a-Bnip3 pathway might be involved in the inhibiting effects of sRAGE on mitochondrial apoptosis during I/R. ...Meanwhile, overexpression or silencing of FoxO3a affected the inhibiting effects of sRAGE on Bnip3 and cleaved caspase- …
Therefore, it is supposed that FoxO3a-Bnip3 pathway might be involved in the inhibiting effects of sRAGE on mitochondrial apoptosis d …
FOXO3 Is Expressed in Ovarian Tissues and Acts as an Apoptosis Initiator in Granulosa Cells of Chickens.
Cui C, Han S, Yin H, Luo B, Shen X, Yang F, Liu Z, Zhu Q, Li D, Wang Y. Cui C, et al. Biomed Res Int. 2019 Jul 11;2019:6902906. doi: 10.1155/2019/6902906. eCollection 2019. Biomed Res Int. 2019. PMID: 31380433 Free PMC article.
FOXO3, which encodes the transcription factor forkhead box O-3 (FoxO3), is a member of the FOXO subfamily of the forkhead box (FOX) family. ...After treatment with a recombinant FOXO3 protein, PARP-1 and caspase 3 protein levels increased, along with mRNA lev …
FOXO3, which encodes the transcription factor forkhead box O-3 (FoxO3), is a member of the FOXO subfamily of the forkhead box …
MicroRNA-122-5p promotes renal fibrosis and injury in spontaneously hypertensive rats by targeting FOXO3.
Liu Y, Dong ZJ, Song JW, Liang LR, Sun LL, Liu XY, Miao R, Xu YL, Li XT, Zhang MW, Zhang ZZ, Zhong JC. Liu Y, et al. Exp Cell Res. 2022 Feb 15;411(2):113017. doi: 10.1016/j.yexcr.2022.113017. Epub 2022 Jan 5. Exp Cell Res. 2022. PMID: 34998813
There were marked increases in miR-122-5p and Kim-1 levels and decreases in FOXO3 and SIRT6 levels in hypertensive rats. Transfection with rAAV-miR-122-5p triggered exacerbation of renal fibrosis, apoptosis and inflammatory injury in SHR, associated with downregulated leve …
There were marked increases in miR-122-5p and Kim-1 levels and decreases in FOXO3 and SIRT6 levels in hypertensive rats. Transfection …
FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model.
Schips TG, Wietelmann A, Höhn K, Schimanski S, Walther P, Braun T, Wirth T, Maier HJ. Schips TG, et al. Cardiovasc Res. 2011 Sep 1;91(4):587-97. doi: 10.1093/cvr/cvr144. Epub 2011 May 30. Cardiovasc Res. 2011. PMID: 21628326
We wanted to study FoxO3 function in the adult heart in vivo by expressing a constitutively active mutant of FoxO3 in transgenic mice. ...As shown by electron microscopy, FoxO3-CA massively stimulated destruction of sarcomeres and autophagy, and induced expre …
We wanted to study FoxO3 function in the adult heart in vivo by expressing a constitutively active mutant of FoxO3 in transgen …
Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy.
Cao DJ, Jiang N, Blagg A, Johnstone JL, Gondalia R, Oh M, Luo X, Yang KC, Shelton JM, Rothermel BA, Gillette TG, Dorn GW, Hill JA. Cao DJ, et al. J Am Heart Assoc. 2013 Apr 8;2(2):e000016. doi: 10.1161/JAHA.113.000016. J Am Heart Assoc. 2013. PMID: 23568341 Free PMC article.
Whereas increases in cardiomyocyte apoptosis were not apparent, we detected robust increases in Bnip3 (Bcl2/adenovirus E1B 19-kDa interacting protein 3), an established downstream target of FoxO3. To test the role of Bnip3, we crossed the caFoxO3(flox);alphaM …
Whereas increases in cardiomyocyte apoptosis were not apparent, we detected robust increases in Bnip3 (Bcl2/adenovirus E1B 19-kDa int …
59 results